The resignations were a possible sign of cracks developing in the regime's base in a nation where nearly all opposition figures have been either jailed or exiled during the 40-year dynasty of the Assad family.
"I cannot tolerate the blood of our innocent sons and children being shed," Sheikh Rizq Abdul-Rahim Abazeid told The Associated Press after stepping down from his post as the mufti of the Daraa region in southern Syria.
The lawmakers, Nasser Hariri and Khalil Rifai, also are from Daraa, which has become the epicenter of the protest movement after a group of teenagers were arrested there for scrawling anti-regime graffiti on a wall in mid-March.
Since then, the relentless crackdown on demonstrations has only served to invigorate protesters whose rage over the bloodshed has all but eclipsed their earlier demands for modest reforms. Now, many are seeking Assad's downfall.
Each Friday, growing numbers of people in cities across the country have taken to the streets despite swift attacks from security forces and shadowy pro-government gunmen known as "shabiha."
Radwan Ziadeh, a visiting scholar at the Institute for Middle East Studies at George Washington University, said the resignations were largely symbolic because the parliament has no real power. But their dissent could encourage others to step down, such as Vice President Farouk al-Sharaa, who is from Daraa, Ziadeh said.
He added Assad met with the lawmakers in recent weeks, promising them that security forces would not shoot protesters.
The uprising in Syria takes its inspiration from the popular revolts that toppled the leaders in Egypt and Tunisia. But Syria is a highly unpredictable country, in part because of its sizable minority population, the loyalty of the country's military and the regime's web of allegiances to powerful forces including Lebanon's Hezbollah and Shiite powerhouse Iran.
Serious, prolonged unrest in Syria would almost inevitably hurt Hezbollah and weaken Iran's influence in the region. But it is not at all clear what factions would have the upper hand if a power vacuum emerges in Syria. There are no organized, credible opposition leaders who can rally followers on the ground or be considered as a possible successor.
The heavy security crackdown on Friday and Saturday came after Assad warned a week ago that any further unrest would be considered "sabotage" after he made the gesture of lifting long-hated emergency laws, which gave security forces almost blanket powers for surveillance and arrest.
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